In your report you can have multiple different layouts and parts of your document. The page layout specifies page size, margins and content of headers and footers. Each part of the report, called a Page Set, uses one or more page layouts. It is in the page set that you define the content of the report. For example you can have a cover page with one layout and no header/footer and one page set with the RDS for each room that has another page layout. You can even have different layouts for different header/footer for odd and even pages. For example:
In order to view the pagination setup, make sure to check the pagination check box in View → Show/hide → Pagination.